{"id":19980,"date":"2026-02-24T12:04:05","date_gmt":"2026-02-24T11:04:05","guid":{"rendered":"https:\/\/www.fondationpierrefabre.org\/faq-items\/quelle-est-la-cause-de-la-drepanocytose\/"},"modified":"2026-05-11T18:24:25","modified_gmt":"2026-05-11T16:24:25","slug":"what-causes-sickle-cell-disease","status":"publish","type":"avada_faq","link":"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/what-causes-sickle-cell-disease\/","title":{"rendered":"What causes sickle cell disease?"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-margin-bottom:30px;--awb-background-color:#f2f2f2;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\"><h1 style=\"text-align: center;\">What causes sickle cell disease?<\/h1>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-2 fusion-text-no-margin\" style=\"--awb-margin-bottom:25px;\"><h2>How is sickle cell disease spread and diagnosed?<\/h2>\n<p>Sickle cell disease is not a contagious condition; it is inherited from parents and passed on to their children. A child must inherit one copy of the mutated gene from each parent to develop the most severe form of the disease. If the child inherits only one copy, they will be a carrier of the sickle cell trait, without developing the disease.<\/p>\n<p><img decoding=\"async\" class=\"lazyload alignnone wp-image-19457 size-medium\" src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-300x169.jpg\" data-orig-src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-300x169.jpg\" alt=\"\" width=\"300\" height=\"169\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27169%27%20viewBox%3D%270%200%20300%20169%27%3E%3Crect%20width%3D%27300%27%20height%3D%27169%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-200x113.jpg 200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-280x157.jpg 280w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-300x169.jpg 300w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-320x180.jpg 320w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-400x226.jpg 400w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-600x339.jpg 600w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-768x434.jpg 768w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-800x452.jpg 800w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-1024x578.jpg 1024w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-1200x678.jpg 1200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-12-scaled-e1771929748843-1536x868.jpg 1536w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><\/p>\n<p>Sickle cell disease is usually diagnosed through a blood test that can identify the presence of haemoglobin S. More specific tests, such as haemoglobin electrophoresis, can also determine the specific type of sickle cell disease. Today, there are rapid and reliable diagnostic tests available to screen for sickle cell disease.<\/p>\n<p><img decoding=\"async\" class=\"lazyload alignnone wp-image-19455\" src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-288x300.png\" data-orig-src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-288x300.png\" alt=\"\" width=\"300\" height=\"313\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27313%27%20viewBox%3D%270%200%20300%20313%27%3E%3Crect%20width%3D%27300%27%20height%3D%27313%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-200x209.png 200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-288x300.png 288w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-400x417.png 400w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-600x626.png 600w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-768x801.png 768w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790-800x835.png 800w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-11-e1771929567790.png 808w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div>\n<p>Learn more: <a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/what-are-the-symptoms-of-sickle-cell-disease\/\" target=\"_blank\" rel=\"noopener\">When do the symptoms of sickle cell disease first appear?<\/a><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-3 fusion-text-no-margin\" style=\"--awb-margin-bottom:25px;\"><h2>What is the risk of having a child with sickle cell disease? And what should be done if there is a risk?<\/h2>\n<p>As the condition is inherited, the risk depends on the genes carried by both parents. Couples at risk are either carriers of the trait or have sickle cell disease themselves.<\/p>\n<p>It is important for parents to know their haemoglobin? status so that they are aware of the risk of having a child with the condition.<\/p>\n<ul>\n<li>If both parents have sickle cell disease, all their children will have sickle cell disease.<\/li>\n<li>If one parent has sickle cell disease and the other is a carrier, there is a 50% chance that each newborn will have sickle cell disease and a 50% chance that they will be a carrier.<\/li>\n<li>If one parent is a carrier and the other is not, there is a 50% chance of having children who are carriers, and no risk of having a child with the condition.<\/li>\n<li>If both parents are carriers, there is a 25% chance that each newborn will have sickle cell disease, a 50% chance of being a carrier, and a 25% chance of having neither sickle cell disease nor being a carrier.<\/li>\n<\/ul>\n<div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div>\n<p>It is strongly recommended that couples find out about their haemoglobin status before considering having children.<\/p>\n<p>Couples at risk (carriers of the trait and those with sickle cell disease) can seek genetic advice to determine the risk of passing on the condition.<\/p>\n<p><img decoding=\"async\" class=\"lazyload wp-image-19462 size-medium alignnone\" src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-300x250.jpg\" data-orig-src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-300x250.jpg\" alt=\"\" width=\"300\" height=\"250\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27250%27%20viewBox%3D%270%200%20300%20250%27%3E%3Crect%20width%3D%27300%27%20height%3D%27250%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-200x167.jpg 200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-300x250.jpg 300w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-400x334.jpg 400w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-600x500.jpg 600w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-768x641.jpg 768w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-800x667.jpg 800w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-1024x854.jpg 1024w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21-1200x1001.jpg 1200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/02\/quelle-est-la-cause-de-la-drepanocytose-21.jpg 1223w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:10px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div>\n<p>Learn more: <a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/what-are-the-symptoms-of-sickle-cell-disease\/\" target=\"_blank\" rel=\"noopener\">What are the clinical signs of sickle cell disease?<\/a><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-4 fusion-text-no-margin\" style=\"--awb-margin-bottom:25px;\"><h2>Why are certain populations more affected?<\/h2>\n<p>Sickle cell disease is more common in certain parts of the world, particularly in sub-Saharan Africa, due to a genetic mutation that originated in that region and provided protection against malaria. Natural selection has increased the prevalence of the sickle cell gene in these populations.<\/p>\n<p><img decoding=\"async\" class=\"lazyload alignnone wp-image-19559 size-medium\" src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-300x212.jpg\" data-orig-src=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-300x212.jpg\" alt=\"\" width=\"300\" height=\"212\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27300%27%20height%3D%27212%27%20viewBox%3D%270%200%20300%20212%27%3E%3Crect%20width%3D%27300%27%20height%3D%27212%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-200x141.jpg 200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-300x212.jpg 300w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-400x283.jpg 400w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-600x424.jpg 600w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-768x543.jpg 768w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-800x566.jpg 800w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-1024x724.jpg 1024w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-1200x848.jpg 1200w, https:\/\/www.fondationpierrefabre.org\/wp-content\/uploads\/sites\/2\/2026\/03\/PLC-9-1536x1086.jpg 1536w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/p>\n<p>Learn more: <a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/what-are-the-symptoms-of-sickle-cell-disease\/\" target=\"_blank\" rel=\"noopener\">How does sickle cell disease progress?<\/a><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-5 fusion-text-no-margin\" style=\"--awb-margin-bottom:35px;\"><p><span style=\"font-size: 10pt;\"><strong>References ___________________________________________________________<br \/>\n<\/strong><em>Organisation Mondiale de la Sant\u00e9. (2020). Dr\u00e9panocytose.<\/em><\/span><br \/>\n<span style=\"font-size: 10pt;\"><em>National Heart, Lung, and Blood Institute. (2022). What Is Sickle Cell Disease?<\/em><\/span><br \/>\n<span style=\"font-size: 10pt;\"><em>Centers for Disease Control and Prevention. (2021). Sickle Cell Disease.<\/em><\/span><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last mod-focus\" style=\"--awb-padding-top:0px;--awb-padding-right:20px;--awb-padding-bottom:0px;--awb-padding-left:20px;--awb-bg-size:cover;--awb-border-color:#717171;--awb-border-bottom:0;--awb-border-style:solid;--awb-margin-top:20px;--awb-margin-bottom:20px;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-6\"><h3>Related questions<\/h3>\n<\/div><div class=\"fusion-text fusion-text-7\" style=\"--awb-margin-top:20px;\"><p style=\"text-align: center; line-height: 3em;\"><span style=\"font-size: 18pt;\"><strong><a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/what-is-sickle-cell-disease\/\" target=\"_blank\" rel=\"noopener\">What is the definition of sickle cell disease?<\/a><\/strong><\/span><br \/>\n<span style=\"font-size: 18pt;\"><strong><a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/what-are-the-symptoms-of-sickle-cell-disease\/\" target=\"_blank\" rel=\"noopener\">What are the symptoms of sickle cell disease?<\/a><\/strong><\/span><br \/>\n<span style=\"font-size: 18pt;\"><strong><a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/how-to-live-with-sickle-cell-disease\/\" target=\"_blank\" rel=\"noopener\">How to live with sickle cell disease?<\/a><\/strong><\/span><br \/>\n<span style=\"font-size: 18pt;\"><strong><a href=\"https:\/\/www.fondationpierrefabre.org\/en\/faq-items\/how-can-sickle-cell-disease-be-combated\/\" target=\"_blank\" rel=\"noopener\">How can sickle cell disease be combated?<\/a><\/strong><\/span><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":18854,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"faq_category":[581],"class_list":["post-19980","avada_faq","type-avada_faq","status-publish","format-standard","has-post-thumbnail","hentry","faq_category-drepanocytose"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What causes sickle cell disease? 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